Geospatial Framework for the Use of Natural Resource Extraction in Public Private Partnerships

Resources for the maintenance and expansion of existing highway infrastructure are scarce. Public Private Partnerships (PPP) are feasible solutions to the concern of lagging investment. PPP are increasingly used for the procurement of services and goods, because of their flexibility and ability to channel private resources. This research addresses the possible implementation of a barter approach in Public Private Partnerships (PPP), which includes natural resources for trade model to offset costs.;Federal law permits the extraction of coal when it is a byproduct of the construction process, coal which under normal circumstances would not be economically feasible to extract. West Virginia law allows PPP to extract coal by surface mining when they develop road beads for new highways. There is no exchange of funds between the coal company and the West Virginia Department of Transportation; the benefits are derived entirely from the construction cost savings for roadbed construction.;This dissertation develops a geospatial method to quantify the availability of natural resources along predetermined roadway alignments. The methodology is divided in three phases: Macroscopic (Level I), Mesoscopic (Level II) and Microscopic (Level III), for the King Coal Highway. The process considers laws and industry best practices in the calculation. The research outcome suggests that there are segments of the road with enough, as well as segments of the road without enough coal

Farmacovigilancia: ¿Qué es cómo aplicarla en un servicio farmacéutico de baja complejidad?

Aplicar un programa de farmacovigilancia en la droguería de parque campestre de farmacenter aplicando los procesos más eficaces para ponerlo en desarrollo el cual se debe enfatizar en aplicacion diaria la farmacovigilancia, garantizando que los profesionales sean los primeros en tener conocimiento suficiente para llevar a cabo sus actividades diarias con éxito.Apply a pharmacovigilance program in the drugstore of Parque Campestre de Farmacenter, applying the most effective processes to put it into development, which should be emphasized in daily application of pharmacovigilance, guaranteeing that professionals are the first to have sufficient knowledge to carry out their activities. successful daily

Biodegradable FeMnSi sputter-coated macroporous polypropylene membranes for the sustained release of drugs

Pure Fe and FeMnSi thin films were sputtered on macroporous polypropylene (PP) membranes with the aim to obtain biocompatible, biodegradable and, eventually, magnetically-steerable platforms. Room-temperature ferromagnetic response was observed in both Fe- and FeMnSi-coated membranes. Good cell viability was observed in both cases by means of cytotoxicity studies, though the FeMnSi-coated membranes showed higher biodegradability than the Fe-coated ones. Various strategies to functionalize the porous platforms with transferrin-Alexa Fluor 488 (Tf-AF488) molecules were tested to determine an optimal balance between the functionalization yield and the cargo release. The distribution of Tf-AF488 within the FeMnSi-coated PP membranes, as well as its release and uptake by cells, was studied by confocal laser scanning microscopy. A homogeneous distribution of the drug within the membrane skeleton and its sustained release was achieved after three consecutive impregnations followed by the addition of a layer made of gelatin and maltodextrin, which prevented exceedingly fast release. The here-prepared organic-inorganic macroporous membranes could find applications as fixed or magnetically-steerable drug delivery platforms

Biodegradable FeMnSi sputter-coated macroporous polypropylene membranes for the sustained release of drugs

Pure Fe and FeMnSi thin films were sputtered on macroporous polypropylene (PP) membranes with the aim to obtain biocompatible, biodegradable and, eventually, magnetically-steerable platforms. Room-temperature ferromagnetic response was observed in both Fe- and FeMnSi-coated membranes. Good cell viability was observed in both cases by means of cytotoxicity studies, though the FeMnSi-coated membranes showed higher biodegradability than the Fe-coated ones. Various strategies to functionalize the porous platforms with transferrin-Alexa Fluor 488 (Tf-AF488) molecules were tested to determine an optimal balance between the functionalization yield and the cargo release. The distribution of Tf-AF488 within the FeMnSi-coated PP membranes, as well as its release and uptake by cells, was studied by confocal laser scanning microscopy. A homogeneous distribution of the drug within the membrane skeleton and its sustained release was achieved after three consecutive impregnations followed by the addition of a layer made of gelatin and maltodextrin, which prevented exceedingly fast release. The here-prepared organic-inorganic macroporous membranes could find applications as fixed or magnetically-steerable drug delivery platforms

Avances en Informática y Automática. Noveno Workshop

[ES]El Máster Oficial en Sistemas Inteligentes de la Universidad de Salamanca tiene como principal objetivo promover la iniciación de los estudiantes en el ámbito de la investigación. El congreso organizado por el Departamento de Informática y Automática que se celebra dentro del Máster en Sistemas Inteligentes de la Universidad de Salamanca proporciona la oportunidad ideal para que sus estudiantes presenten los principales resultados de sus Trabajos de Fin de Máster y obtengan una realimentación del interés de los mismos. La novena edición del workshop \Avances en Informática y Automática", correspondiente al curso 2014 - 2015, ha sido un encuentro interdisciplinar donde se han presentado trabajos pertenecientes a un amplio abanico de líneas de investigaci ón, desde los sistemas multiagente y la visualización de la información hasta la minería de datos pasando por otros campos relacionados. Todos los trabajos han sido supervisados por investigadores de reconocido prestigio pertenecientes a la Universidad de Salamanca, proporcionando el marco idóneo para sentar las bases de una futura tesis doctoral. Entre los principales objetivos del congreso se encuentran: Ofrecer a los estudiantes un marco donde exponer sus primeros trabajos de investigación. Proporcionar a los participantes un foro donde discutir ideas y encontrar nuevas sugerencias de compa~neros, investigadores y otros asistentes a la reunión. Permitir a cada estudiante una realimentación de los participantes sobre su trabajo y una orientación sobre las futuras direcciones de investigación. Contribuir al desarrollo del espíritu de colaboración en la investigaciónDepartamento de Informática y Automátic